Whitish background colour and whitish halo around blood vessels corresponding to proliferation of keratinocytes, in combination with a central crusted area is characteristic of a keratinizing tumour. In this case an invasive squamous cell carcinoma.

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This is a pattern often seen in combined naevi in adults which is known as the the ‘fried-egg pattern’. This consists of an elevated section in the center with globules/cobblestones (this can also be structureless brown to pale pigmentation) and a flat portion at the periphery, typically with a reticular pigment network.

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There is a pseudonetwork with asymmetric pigmentation of follicular openings to form rhomboidal structures. This is a lentigo maligna melanoma of Breslow’s thickness 0.2mm

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The most striking diagnostic feature in this melanoma, is the presence of asymmetric collections of globules varying in size and colour. A small area with remnants of a pigment network is indicated.

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This is a reticular naevus characterized by a regular pigment network which gradually fades peripherally.

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The most striking feature in this melanoma is the area composed of blue pepper-like granules over a white scar-like background which represents regression corresponding to the falt portion of the tumour. There is also a large area of blue-white veil corresponding to the elevated nodular oart of the tumour. Note the presence of a pigment network.

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This is an actinic keratosis with a red pseudonetwork showing hair follicles filled with keratin plugs on a red background. Around the hair follicles some coiled vessels can be seen. The overall appearance resembles the surface of a strawberry (inset) hence the name strawberry pattern.

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This is a melanoma with a large white scar-like area of regression. A reticular pigment network is evident.

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There are dotted vessels and reticular depigmentation in this non-pigmented Spitz/Reed naevus

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